Nyob rau hauv xyoo tas los, Molecule Nad⁺ (Nicotinamide Adenine Linucleotide) tau nyiam cov kev tshawb fawb hauv kev tshawb fawb hauv cov kab mob cellular, kev laus, thiab ntau yam kab mob. Tab sis dab tsi raws nraim yog nad⁺, thiab vim li cas nws tseem ceeb heev rau tib neeg kev noj qab haus huv?
Nad⁺ yog dab tsi?
Nad⁺ yog coenzyme pom nyob rau hauv txhua cell uas muaj sia nyob. Nws muaj nyob hauv ob daim ntawv: daim ntawv oxidized (nad⁺) thiab daim ntawv txo (nadh). Ob lub xeev no yog ib feem ntawm cov txheej txheem sib txawv uas ua rau hloov chaw ntawm hluav taws xob thaum redox (oxidation- txo) kev sib haum xeeb. Nad⁺ yog qhov tseem ceeb rau kev tsim hluav taws xob, DNA kho kom zoo, thiab ntau txoj kev metabolic.
Tshawb pom nyob rau xyoo 1906 raws li ib qho khoom sib xyaw ua ke uas ua kom cov poov xab fermentation, Nad⁺ tom qab qhia tau tias yuav tsis pom kev rau Redox Reds. Nws lub npe yog hais txog tus qauv tseem ceeb, tsis hais nws lub xeev oxidation. Daim ntawv oxidized (nad⁺) thiab daim ntawv txo (nadh) yog biochemically decconvertible nyob rau hauv lub cev.
Keeb kwm kev tshawb fawb hauv Nad⁺ Tshawb Fawb
NAD tau txheeb xyuas qhov tseem ceeb hauv kev hloov pauv redox.
Nad⁺ tau pom tias yog ib qho kev ua kom zoo rau poly (adp - ribose) polymerases (enzymes koom nrog DNA kho thiab Gene kev cai.
Kev tshawb nrhiav hauv tsev neeg cov tsev neeg Sirtin (Littly Sir2), uas nws txoj haujlwm yog nyob ntawm nad⁺ thiab cuam tshuam nrog livespan txuas ntxiv thiab muaj kev ruaj khov.
Mammalian sirtuins tau nrhiav pom los ua cov luag haujlwm tseem ceeb hauv kev laus, cov lus teb kev nyuaj siab, thiab cov kev cai metabolic. Tshwj xeeb, Harvard Spyiver David Sinclair txoj hauj lwm qhia tau qhov ncaj qha ntawm nad⁺ qib thiab kev laus txheej txheem.
Nad⁺ thiab Cellular Metabolism
Nad⁺ yog ib tus neeg ua haujlwm nruab nrab hauv mitochondrial hluav taws xob ntau lawm, tshwj xeeb tshaj yog nyob rau hauv lub glucose, cov rog, thiab amino acids rau hauv ATP {{lub ntsiab lub zog lub zog ntawm cov hlwb. Tswj cov nad⁺ txaus yog qhov tseem ceeb rau kev txhawb nqa txoj haujlwm ntawm cov kabmob thiab cov ntaub so ntswg.
Nad⁺ thiab DNA kho
Nad⁺ ua haujlwm ua qhov tseem ceeb rau cov kab mob ntaus pob cuam tshuam nrog ntau DNA kho txoj hauv kev, nrog rau kev tsim kom zoo thiab ib qho {} {} strand tawg. Kev poob qis hauv Nad⁺ Qhov Cuam Tshuam DNA kho, ua rau genomic instability, cellular senescation, thiab muaj kev txhim kho kev mob cancer.
Lub luag haujlwm ntawm Nad⁺ hauv Racradian atherosclerosis thiab kev tiv thaiv kab mob
Nad⁺ tseem tswj hwm hluav taws xob nrawm los ntawm kev ua kom cov ntsiab lus teev cov ntsiab lus tseem ceeb, ua kom pw tsaug zog, cov kev pw tsaug zog, thiab cov lus teb tsis sib luag. Nws qhov kev zam nrog lub hnub nyoog tuaj yeem cuam tshuam cov kev sib dhos no, tsis pom kev pw tsaug zog thiab kev noj qab haus huv tag nrho.
Ib qho ntxiv, NADO txhim kho kev ua haujlwm ntawm lub hlwb tiv thaiv xws li macrophages thiab ntuj killer (nk) hlwb, ntxiv dag zog rau cov kab mob pathogens thiab malignant hlwb.
Hnub nyoog - Qhov Kev Txiav Txim thiab Kab Mob Ntaus
Kev laus yog nrog kev nce qib zuj zus hauv NADUN qib. Qhov kev txo qis no yog txuam nrog ntau lub hnub nyoog -} cov kab mob uas cuam tshuam nrog:
Neurodegenerative: Alzheimer tus kab mob, Parkinson tus kab mob, thiab lwm hom kev txawj poob.
Kab mob metabolic: Hom 2 mob ntshav qab zib thiab kev rog rog -} cov kev tsis sib haum xeeb.
Kab Mob Cardiovases: Atherosclerosis, myocardial kawg.
Mob mob ntev: Xws li mob hnyuv (IBD).
Tsawg Nad⁺ Qib Theem Ua Haujlwm Mitochondrial Ua Haujlwm, Zog metabolism Quav, DNA kho DNA, thiab kev tiv thaiv kab mob DNA, thiab kab mob tsis poob thiab kab mob.
Kho lub peev xwm: Rov kho dua NADUN
Txhawm rau tawm tsam qhov poob hauv Nad⁺, ntau yam cov tswv yim tau tshwm sim. Qhov ua tau zoo tshaj plaws thiab dav nyob rau hauv txoj hauv kev yog kev txhawb nqa nrog NADA ua ntej. Cov no suav nrog:
Nicotinamide MononucleAride (NMN): Kev qhia txog kev ua haujlwm ncaj qha Nada ncaj qha qhia kom sai ntau qib hauv tsiaj thiab tib neeg kev tshawb fawb.
Nicotinamide riboside (NR): Ib qho xyoob ntoo muaj peev xwm muaj peev xwm ntawm kev txhawb nqa nad⁺ hauv ntau cov ntaub so ntswg.
Niacin (nicotinic acid)thiabNicotinamide (nam): Cov vitamins B3 uas tseem yuav ua rau Nad⁺ Biosynthesis.
Cov tebchaw no tau pom muaj kev cog lus hauv kev txhim kho mitochondning, tiv thaiv cov leeg nqaij, thiab thim cov leeg nqaij los ntawm kev txhim kho ATP tiam thiab txo qhov o.
Tshaj dhau ntxiv ntxiv: meej nyob rau hauv nad⁺ kev hloov kho
Thaum prefursor ntxiv muaj cov txiaj ntsig tseem ceeb, nyob twj ywm. Lub xyoob thiab nqus ntawm cov molecules no nyob ntawm xws li kev xa me nyuam, cov plab me me ntawm cov xwm txheej. Ntxiv mus, lub dysreculation ntawm nad⁺ metabolism- Tshwj xeeb cuam tshuam nrog enzymes xws li}} puas tuaj yeem ua rau mob qog kom tsim nyog.
Yog li, kho tau hloov kho ntawm Nad⁺ txoj kev yuav tawm los ua cov tswv yim zoo heev xws li mob qog noj ntshav, ibd, thiab nurodegeneration.
Nada Dealiciency: Vapsical Condercase
Nada tsis txaus, xws li uas tau los ntawm Niacin tsis txaus, ua rau pellagra tsis muaj zog, ua rau pellagra {}} tus cwj pwm los ntawm dermatitis, raws plab, thiab dementia. Txawm tias qhov kev poob qis hauv Nadaus tau nkag siab txog kev cuam tshuam ntawm kev kho cellular, kev tsim hluav taws xob, thiab ntev.
Qib NADON tsawg yuav ua rau:
Nrawm nrawm thiab txo qis ntev ntev
Lub zog tiv thaiv thiab cov metabolic tsis sib xws
Impaired DNA kho thiab genome tsis muaj zog
Lub cev tsis muaj zog thiab ua mob ntev
Neurological thiab Organ Dysfunction
Tag
Nad⁺ yog deb tshaj qhov yooj yim coenzyme - nws yog tus tswv kev tswj hwm kev noj qab haus huv thiab kev laus. Los ntawm lub zog metabolism rau DNA kho, los ntawm cov kab mob circadian, nad⁺ lus dag ntawm lub plawv ntawm lub plawv dhia sib npaug. Raws li kev tshawb fawb tau nce zuj zus, tsom rau Nador tej tswv yim txum ua kom zoo nyob hauv txoj kev tshiab hauv kev tiv thaiv tshiab hauv kev tshawb fawb tshiab, thiab kev kho mob ntawm {}} cov kab mob uas muaj feem xyuam.