Txoj kev npaj ntawm ergothionein

Muaj peb txoj hauv kev los npaj ergothionein: tshuaj synthesis, extraction, thiab biological fermentation synthesis.
Cov tshuaj synthesis ntawm levoergotamine sulfide yog ib qho nyuaj heev, thiab ntau txoj kev synthesis tsis tau ua tiav qhov kev xav tau vim yog ib nrab lossis ua tiav racemization. Qhov nyuaj ntawm kev sib txuas yog tias nws nyuaj rau kev npaj cov khoom siv raw 2-mercaptoimidazole, thiab acidity ntawm alpha carbon ua rau cov tshuaj tiv thaiv kab mob racemization. OXIS International yog thawj lub tuam txhab tsim kom muaj txiaj ntsig zoo thiab kev lag luam rau kev sib txuas ntawm ergothioneine, thiab tau thov rau patent xyoo 1995 los ntawm kev qhia thiol pawg rau hauv imidazole rings. Txawm li cas los xij, vim muaj kev nyuaj rau kev ua kom muaj kev nyab xeeb ntawm cov khoom siv hluavtaws, cov khoom siv hluavtaws kim, cov nqi hluavtaws siab, thiab cov khoom lag luam siab, daim ntawv thov ntawm ergotamine yog txwv.
Txoj kev siv tshuaj lom neeg lub cev rho tawm ergothionein los ntawm lub cev ntawm cov txiv hmab txiv ntoo ntawm cov kab mob noj tau, cov ntshav npua, cov ntaub so ntswg tsiaj, ergot, thiab nplej. Txawm li cas los xij, cov ntsiab lus ntawm ergothionein nyob rau hauv cov ntaub ntawv raw saum toj no tseem tsawg heev, thiab muaj teeb meem xws li impurities siab nyob rau hauv cov ntaub ntawv raw, tshuaj residues, thiab siab extraction nqi, uas txwv tsis pub siv ergothionein thiab tsis haum rau industrialization;
Lub biosynthesis ntawm ergothionein los ntawm kev sib sib zog nqus fermentation tshuab ntawm nceb mycelium yog lub ntsiab kev taw qhia rau cov nqi qis thiab loj-scale zus tau tej cov ergothionein. Cov txheej txheem fermentation tswj cov txheej txheem xws li kev tswj hwm cov txheej txheem metabolic tuaj yeem txhim kho cov txiaj ntsig ntawm ergothionein, txo cov nqi tsim khoom, thiab tseem ceeb tshaj, ua kom cov khoom muaj kev nyab xeeb thiab nthuav dav qhov chaw thov ntawm ergothionein.